Annals of Oncology 2008 19(6):1031; doi:10.1093/annonc/mdn380
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ADAM-17 predicts adverse outcome in patients with breast cancer
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ADAM-17 is a matrix metalloproteinase-like enzyme involved in
the release of several ligands that have been shown to promote
both cancer formation and progression, including transforming
growth factor-

, amphiregulin, heparin-binding epidermal growth
factor, epiregulin and tumor necrosis factor-

. Consistent with
this, ADAM-17 has been implicated in tumor formation/progression;
work in breast cancer cell lines in culture has shown that ADAM-17
promotes both proliferation and invasion,
. . . [Full Text of this Article]
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Prognosis of advanced hepatocellular carcinoma
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Bortezomib, doxorubicin and dexamethasone in multiple myeloma
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Changes in breast cancer incidence and mortality
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